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For example, in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model of PD

These lead to oxidative and nitrosative stress, respectively, a condition where cellular structure and function are more damaged, thereby disrupting intracellular homeostasis

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Reduced GSH is deployed through two enzyme families: glutathione peroxidases ( GPX1-8 ) that use GSH to neutralize hydrogen peroxide and lipid hydroperoxides (producing GSSG), and glutathione S-transferases ( GSTM1, GSTT1, GSTP1 ) that conjugate electrophilic xenobiotics and endogenous reactive species to GSH for excretion

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