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Nanosized drug delivery systems offer a potential solution to this problem

doi: 10.1126/science.1108190 85 SusiarjoMHassoldTJFreemanEHuntPA

So we were a little bit on this, you know, seesaw until we got the right protocol together and, and you know, ironically enough managed to do that with botanicals and not prescriptions, which I'm not knocking prescriptions, we absolutely did that as well

Mechanosensitive Piezo receptors (particularly the Piezo1 subtype) are found in the injury perception of the peripheral trigeminal nerve, and high-dose injections of Yoda1 can extend the meningeal arteries innervated by the trigeminal afferent nerve, leading to the development of migraines (Mikhailov et al., 2019)

KvestadIHysingMShresthaMUlakMThorne-LymanALHenjumSet al

So super important work