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In a mouse model of AD, treatment with EGCG-loaded nanoparticles (EGCG-NPs) was associated with decreased expression of necroptosis-related markers including RIPK1, RIPK3, and MLKL, as well as a reduction in Terminal deoxynucleotidyl transferase dUTP Nick-End Labeling- (TUNEL-) positive keratinocytes, suggesting potential inhibition of keratinocyte necroptosis (Han et al., 2022)

[17] The importance of lysyl oxidase-derived cross-linking was established from animal studies in which lysyl oxidase was inhibited either by nutritional copper-deficiency or by supplementation of diets with -aminopropionitrile (BAPN), an inhibitor of lysyl oxidase