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Cellular senescence and the aging brain

10.1073/pnas.1212976110 79 SunD.WangJ.ToanS.MuidD.LiR.ChangX.et al (2022)

Tian, Yan-Jie, et al

In vitro co-immunoprecipitation and fluorescence polarisation assays have investigated the binding affinity of Proxofim for the p53 interaction domain, examining whether the DRI construct competitively displaces endogenous FOXO4 from the FOXO4-p53 complex in senescent fibroblast cultures