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The addition of SHLP3 to gentamicin-exposed explants resulted in a significant decrease in the immunofluorescence signals of p-AKT-S473 and p-AMPK-172 in both cochlear turns

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Further biochemical analysis revealed that itaconation of Cys239 on FYN (a tyrosine kinase) enhances its kinase activity in macrophages

There is emphasis on the role of increased intestinal permeability and how the subsequent translocation of luminal contents could be involved in the development and/or exacerbation of autoimmune diseases