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Coping with oxidative stress in reproductive pathophysiology and assisted reproduction: melatonin as an emerging therapeutical tool

The resulting mitochondrial disruption not only triggers apoptosis but also stimulates innate immune pathways, including the NLRP3 inflammasome and the cGASSTING axis, amplifying local inflammation and enhancing immune surveillance [282]

PLoS ONE 8(10):e77505 Lacerda AF et al (2014) Antifungal defensins and their role in plant defense

There are limited data to indicate that hormone therapy may stimulate the growth of residual ovarian or endometrial tissue after total hysterectomy and bilateral salpingo-oophorectomy if all visible disease was removed (42)

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3.2 ROS-mediated inflammatory signaling pathways NF-B is a key regulator of inflammatory and immune responses and increases the expression of pro-inflammatory cytokines such as TNF- and IL-1 by up-regulating gene expression through enhanced transcription activating mRNA stabilization (Shen et al., 2019