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Paraptosis Paraptotic cells are characterized by unique features, including cytoplasmic vacuolation arising from extensive ER and mitochondrial dilatation [147]

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Iron serves a dual role in ferroptosis: It promotes ROS accumulation via the Fenton reaction and serves as a key element in enzymes such as LOXs

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The condition arises from a constellation of interconnected biological mechanisms involving mitochondrial dysfunction, immune dysregulation, neuroendocrine imbalance, and cellular oxidative stress