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gingivali s infection enhances programmed death-ligand 1 (PD-L1) expression on dendritic cells within tumor microenvironments and lymph nodes through Akt/STAT3 pathway activation, subsequently impairing CD8 + T cell functionality ( + T cells

Yang et al., 2017)

(E, F) Paraffin sections of tumor samples were used for immunohistochemical staining with antibodies against SLC3A2 or Ki-67

Per the NIH Office of Dietary Supplements, only a fraction of orally ingested vitamins (often 1020% for water-soluble nutrients in compromised gut absorption) reach systemic circulation, while intravenous delivery achieves close to 100% bioavailability