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This effect of RRM1 silencing on erastin2-induced ferroptosis was specific: RRM1 silencing did not inhibit cell death in response to several mechanistically distinct small molecule inducers of apoptosis or other forms of non-apoptotic cell death that are not directly linked to intracellular GSH metabolism (Ko et al, 2019) (Fig S4A)

A new puffing pattern induced by temperature shock and DNP in Drosophila

L-Glutathione (GSH), especially in nanoparticle slow-release form, maintains redox tone but excessive co-delivery creates a reductive stress, paradoxically inactivating Nrf2, SIRT3, and AMPK, the very genes responsible for antioxidant renewal

Consistently, low-dose intranasal administration of RNs has been investigated for neuroprotection in an EAE mouse model of MS

Cel Sci 127, 36493658

doi: 10.1002/eji.200324833 52 ElliottD