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A deficiency may lead to neurological problems including memory issues and numbness in the hands and feet due to nerve damage

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Neurologic manifestations are caused by progressive demyelination and can include peripheral neuropathy, areflexia, and the loss of proprioception and vibratory sense

However, unlike a recent report where constitutive loss of IGF-1Rs specifically in the myocardium of male mice prevented age-related alterations to the heart 30 , late-life mAb treatment failed to preserve or restore these same parameters in male animals (Fig

Among the DEG identified, 2,699 had decreased (1,364) or increased (1,335) expression after treatment with B12 ( Figure 5 )

Future studies will be needed to elucidate the role of these metabolites in the behavioural anomalies in the 22q11.2DS mouse models