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Traina, T

In addition to being a precursor for glutathione synthesis, and the principal methyl donor for nucleic acid, phospholipid, histone, biogenic amine, and protein methylation, methionine metabolites can participate in polyamine synthesis

2.12 Homology modelling of UA transporters The transporters of URAT1, GLUT9, OAT1, and ABCG2 lack structural information ( 2.13 Molecular docking The proteins URAT1, GLUT9, OAT1 and ABCG2 were employed as receptor models, whereas Saikosaponin A, Tanshinone IIA, Schisandrol B and Ganoderic acid A served as ligand molecules, representing the active constituents in the drug-containing sera of Wuling capsule

PMCID: PMC9031130

Similarly, a cross-sectional study from Iran that involved 4,763 adults demonstrated that depressed individuals had a significantly increased risk of constipation, with an adjusted odds ratio (OR) of 1.69 (95% CI: 1.372.09) ( Longitudinally, bidirectional temporal relationships exist between chronic constipation and depression

However, a similar analysis for the change in platelet count from beginning of phase 1 to the beginning of phase 2 was performed, with excretion of toxic metals after the 9 th dose of DMSA and change in glutathione as the dependent variables