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243 Each subtype of p38MAPK has unique functions due to differential expression across tissue types and different regulatory kinases and downstream genes, hence their targeting comes with adverse effects

28,29 Symptoms may initially be mild, but they gradually worsen as the disease progresses

Xie, A.M

1111 Methotrexate should be used with extreme caution in patients with infection, peptic ulcer, ulcerative colitis, or debility, and in very young or geriatric patients

Widera D, Mikenberg I, Elvers M, Kaltschmidt C, Kaltschmidt B