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In terms of immunomodulators: neutralizing antibodies or receptor antagonists targeting metabolic products (e.g., lactate, kynurenine) can block the metabolic abnormality-inflammation vicious cycle (107, 126, 127)

Lindeman B, Johansson Y, Andreassen M, Husy T, Dirven H, Hofer T, Knutsen HK, Caspersen IH, Vejrup K, Paulsen RE, Alexander J, Forsby A, Myhre O (2021) Does the food processing contaminant acrylamide cause developmental neurotoxicity

During detoxification regimens, toxins stored in fat tissues are mobilized and activated by CYP450 enzymes to intermediate substances, leading to a demand for glycine by Phase II enzymes increases

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10.1007/s00403-021-02267-2 178 Najahi-MissaouiW.ArnoldR

Musculoskeletal Science & Practice 2019;40:10-20 Mellor R, Bennell K, Grimaldi A, Nicolson P, Kasza J, Hodges P, Wajswelner H, Vicenzino B