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10.1186/s12974-023-02776-z 71 LiuT

[DOI] [PMC free article] [PubMed] [Google Scholar] [30].Essex DW, Li M, Feinman RD, Miller A

Nasal irrigation with saline is usually used in acute rhinosinusitis and may improve mucociliary clearance but evidence is limited to support its use.3,4 Antibiotics are commonly prescribed for treatment and their use has been suggested to shorten the time to cure acute bacterial rhinosinusitis

Oral estrogenic preparations are considered to be pro-inflammatory because hepatic metabolism of 17-estradiol produces proinflammatory metabolites in higher concentrations than might be produced by more slowly absorbed transdermal products