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Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation

First, although the application of lessons gained from the ATSP-7041 library resulted in significant improvements in a distinct chemical series (the d PMI-d peptides), it is important to highlight that both series are directed towards the same target(s) (Mdm2/X)

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First, isolated mitochondria rapidly consume ADP at subsaturating concentrations, a phenomenon first identified in 1955 as the state 3/4 transition by Chance and Williams [29]

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