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ESCEO-WHO2 Ko S

McEvoy GK, ed

It stays active in the bloodstream, reaching tissues throughout the body and exerting its effects for over a full day after each injection

This reduction in circulating histamine may help mitigate the inappropriate vasodilation that drives severe blood pooling and orthostatic intolerance

Of note, CpG and CL097 but not poly:IC stimulated IL-6 secretion in this assay, while poly:IC was the most efficient stimulus in inducing IFN secretion by CD11c + DCs (Fig