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Jan 2013;12(1):7-24

Cancer 84 , 6980 (2017) J.M

Factors influencing ADME properties of therapeutic antisense oligonucleotides: physicochemical characteristics and beyond

68 In non-transformed cells, NRF2 promotes the entry of cysteine into the taurine synthesis pathway via CDO1, 69 and modestly limits the accumulation of cysteine and glutathione synthesis

Overall, 42 and 45 metabolites were identified in pHLS9 and HepaRG systems, respectively, with metabolite number increasing alongside alkyl chain length and heterocyclic substitution