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Biomarkers of biologically effective doses for mutagenic and carcinogenic chemicals can provide an estimate of the interaction between chemicals in smoke and target biologic tissues or bodily fluids

[22] As of August 2017, regulatory compliance deadlines relating to premarket review requirements for most e-cigarette and e-liquid products have been extended from November 2017 to August 8, 2022, [24] [25] which attracted a lawsuit filed by the American Heart Association, American Academy of Pediatrics, the Campaign for Tobacco-Free Kids, and other plaintiffs

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