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doi: 10.1111/j.1600-079X.1997.tb00310.x 47 PanHLiHWuSLaiCGuoD

(2) preclinical-to-clinical gaps persist in dose optimization (e.g., PK/PD modeling for febuxostatSEDDSs) and delivery route validation (e.g., human skin studies for elastic liposomes), with limited data on patient compliance and real-world applicability