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Defective mitophagy sensitive to ceramides has also been reported in PD (Vos et al., 2021)

I think the very important thing for this trial is, it is a different kind of patient population

These same peptides as well as 295: 306 and the tryptic peptide 299:306 were alkylated with 5 mM NEM for 30 minutes at 37 C then acidified to pH less than 3.0 with formic acid

Add 75 ul of 4-methylumbelliferyl phosphate (MUP) or p-nitrophenyl phosphate (NPP) substrate solution to each well and incubate 1 hour at room temperature

Thus, alterations of p53 function can a priori result in changes of tumor cell sensitivity to the drugs, in particular, in multidrug resistance

It is preventable by starting slow and using appropriate concentrations