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The complement component 5a (C5a) is an essential mediator of the febrile response to LPS (Li et al., 2002)

By delivering them as an injection rather than a pill, MIC-B12 bypasses gut absorption issues and supports more reliable, steady levels

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Tramadol abuse, with its dose-dependent risks of physical dependence, opiate addiction and overdoses in the general population, is of concern and has led to it being a controlled drug in many countries

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Moving forwards, it would be beneficial for further research to progress to larger animal models