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2009 Jul;8(8):697701

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Cancer cells typically reach the spine via the bloodstream, after which they enter the bone marrow and begin to multiply

It is redox-active, meaning it readily participates in reactions that generate oxidative stress

Increased levels of miR-144 have been found in a subset of HbSS patients with typical severe anemia and reduced NRF2 protein levels, causing a reduction of GSH regeneration and impairing cell response to OS, thereby providing a possible mechanism for the increased anemia severity seen in these patients [221]

In total, 14 of the 16 patients had significant pain relief when given an intraarticular knee injection with BPC-157 or BPC-157 plus TB4