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36 Because of its high incidence among populations in which malaria was once endemic, G6PD deficiency is thought to have conferred a selective advantage against infection by falciparum malaria

Pemmaraju N, Carter BZ, Kantarjian H, Bose P, Kadia T, Jabbour E, DiNardo C, Daver N, Estrov Z, Cortes J, Garcia-Manero G, Zhou L, Mak PY, Salinas K, Tuttle C, Piere S, Popat U, Verstovsek S

It is hypothesized that while non-pathogenic bacteria utilize cholesterol oxidase to degrade cholesterol as a nutrient source, pathogenic species exploit the enzyme to alter host lipid membranes and facilitate infection of macrophages [127]

: Design and synthesis of emodin derivatives as novel inhibitors of ATP-citrate lyase

Our findings are in line with several other studies aimed to elucidate the fine redox regulatory mechanisms that lie behind the correct cell cycle progression

Cost and transparency : There should be transparency in the cost of the treatment and how often you will need it