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Glycine must occupy its modulatory binding site on the NMDA-receptor complex for glutamatergic neurotransmission to occur fully

The underlying pharmacology is well described in peer-reviewed literature, though clinical effect sizes vary by indication, dosing, individual factors, and adherence

doi: 10.1189/jlb.3MR0316-106R [DOI] [PMC free article] [PubMed] [Google Scholar] 205

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In the cells, the interaction of excess superoxides with excess nitric oxide results in the generation of peroxynitrite which specify the chronic disease conditions of stroke, myocardial infarction, chronic heart failure, diabetes, circulatory shock, chronic inflammatory diseases, cancer, and neurodegenerative disorders [12]

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