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Lab Invest 92 , 224235 (2012)

Futur J Pharm Sci 9:74 Cheng G, Hight Walker A (2010) Transmission electron microscopy characterization of colloidal copper nanoparticles and their chemical reactivity

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The copper complex itself is not optional decoration: the copper ion is what activates the receptor signaling at fibroblast surfaces

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According to experts recommendations (e.g., American Academy of Neurology), the first-line treatment medications in migraine prevention are: -blockers (propranolol), antiepileptic drugs (topiramate, valproic acid), and antidepressants (amitriptyline)