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For the remaining 63 spectra, mean fit error was 38%

We demonstrate that AA147 activates NRF2 through a mechanism involving metabolic activation to a reactive electrophile and covalent modification of KEAP1 a mechanism analogous to that involved in AA147-dependent activation of ATF6

He C, Zhang Z, Li B, Tian S

Gut microbiotabile acidintestinal farnesoid X receptor signaling axis orchestrates cadmium-induced liver injury

Conclusion The neurotoxic triad is characterized by excitotoxicity, oxidative stress, and neuroinflammation, with each aspect of the triad being able to perpetuate the others inside of the nervous system