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Description

2011;6(9): e23914

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GSH depletion in transfected HepG2 cells by BSO-treatment slightly decreased GSTP1 activity in cell lysates

(Budapest, Hungary)

revealed that direct reduction of glutamine exerted a stronger anti-leukemic effect compared to inhibition of GLS activity in FLT3-ITD mutant cells, suggesting that FLT3-ITD mutant cells may rely on a paracrine pathway of glutamine metabolism for glutamate production [19]