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Furthermore, given the aforementioned purported mechanisms for the improving effects of L-carnitine/synbiotics on weight or metabolic parameters, it could be conceived that concomitant supplementation of L-carnitine and synbiotics may confer more pronounced impacts on these indicators, potentially through simultaneous modulation of energy homeostasis (56, 57), in a complementary or synergistic manner probably mediated through concurrent targeting of metabolic/inflammatory signaling pathways including CPT-Ia ( Strengths and limitations As far as we know, this clinical trial appears to be the first to compare the impacts of co-supplementation of L-carnitine + synbiotic vs

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