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And then if Ive got the time doing another round to allow for the back and forth blood flow

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To evaluate differential expression (DE) attributable to hypoxia, HIF1 and HIF2 (EPAS1) knockdown, a trivariate model was applied using limma

Stimulation was achieved by supplementing the serum-free tube-induction medium containing EBC-1 supernatant (50 g/ml), 3D culture supernatant derived from Lu99 cells described below or rhVEGF-A (30 ng/ml) with or without a mouse monoclonal anti-IgG2B antibody (10 g/ml) or an anti-VEGF-A neutralising antibody (10 g/ml) at the indicated time points

If you believe the positive DSIP studies, then the conventional ~100 mcg is far below anything ever shown to do anything a single 5 mg vial would contain barely three studied doses