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Once complexed by haem-targeting proteins or xenosiderophores, a set of TonB-dependent transporters (TBDTs) are required to transport the haem/iron into the periplasmic space, followed by transport across the inner membrane by ATP-binding cassette (ABC) transporters (Sgheiza et al., 2017)

This dynamic approach ensures optimal detoxification results while addressing individual challenges

Regulation of asparagine levels is tightly linked to cellular stress responses

The study found that the exosomal SP94-Lamp2bRRM, which targets HCC, aids in delivering small interfering RNA to improve sorafenib-induced ferroptosis by inhibiting the expression of GPX4 and DHODH

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