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BMC Plant Biol 20:532

Shree Harini, K

Ponesimod protects against neuronal death by suppressing the activation of A1 astrocytes in early brain injury after experimental subarachnoid hemorrhage

It also activates the Nrf2 pathway, which upregulates antioxidant enzymes like CAT, SOD2, and HO-1, strengthening the cellular response to oxidative stress 197,199

This gap in research is another reason to use moderate, evidence-based doses rather than assuming "more is better." If you're taking medications for cancer treatment, diabetes, or cardiovascular conditions, consult your healthcare provider before adding glutathione supplements, as potential interactions could affect medication effectiveness or create unexpected complications

Preoperative oral administration of L-theanine and cystine regulates the oxidation-reduction cycle of GSH, decreases the inflammatory cytokines, alleviates the infiltration of white blood cells, and reduces the damage of inflammatory injury to the body tissues, thus improving the survival rate after intestinal ischemia-reperfusion in a dose-dependent manner [32]